If victim is conscious and alert, give 24 cupfuls of milk or water. Skin contact wash off immediately with plenty of water for at least 15 minutes. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Perchloric acid hclo 4, cas 7601903, is one of the strongest acids known. Perchloric acid must not be stored in the same fire compartment as flammable and combustible solids, gases, and. Most perchloric acid is sold as 60%62% or 70%72% acid in water. Perchloric acid pca precipitation to remove interfering proteins from your sample.
This chemical inventory is oshas premier onestop shop for occupational chemical information. Perchloric acid is a strong mineral acid commonly used as a laboratry reagent. This msds has been prepared according to the hazard criteria of the controlled products regulations cpr and the msds contains all of the information required by the cpr. Usually encountered as an aqueous solution, this colorless compound is a strong acid comparable in strength to sulfuric acid and nitric acid. Chemical identification and physical properties exposure limits sampling information. Electroanalytical studies on the interaction of 4n, n. Perchloric acid is the inorganic compound with the formula hclo4. Many bioassays require removal of protein from samples prior to analysis. Perchloric acid 70% materials, strong dehydrating agents. The final trichloroacetic acid concentration given in the procedure above is 25 % wv. Perchloric acid hclo 4, an oxygen acid of chlorine, is strongly acidic in nature. It would be very helpful for my work if anyone can suggest a way to remove perchloric acid from my.
Sigmaaldrich offers a number of perchloric acid products. Perchloric acid university of california, berkeley. Guidelines for using perchloric acid perchloric acid hclo4 is a strong mineral acid. Nitric acid has poor oxidising strength below 2 m but is powerful in its concentrated form. Dec 02, 2017 concentrated perchloric acid is used to disslove rocks and minerals for chemical analysis. The analysis of small molecules in biological samples is frequently hindered by the presence of protein and various enzyme activities.
Osha occupational chemical database occupational safety and. How do i remove perchloric acid from my samples so that it can be loaded onto hplc columns. Application perchloric acid has been used to deactivate chloraminet during the spectrophotometric determination of collagen content of the rat tibialis anterior ta tendons and tendon constructs. Measure the leaf area and preweigh leaf before gas exchange experiment. The osha lab standard requires a cemical hygiene plan tat includes standard operating hh. All perchloric acid digestions are required to be done in a perchloric acid hood. Perchloric acid safety guidelines perchloric acid is a strong mineral acid commonly used as a laboratory reagent. Wear appropriate protective neoprene or polyethylene gloves to prevent skin exposure. Perchlorate has been detected in rain and snow samples from florida and lubbock, texas. Perchloric acid guidelines faculty of science university of ottawa. Sample dissolution many oxidizing agents used in sample dissolution convert metals to a stable oxidation state displacing hydrogen from hydroc hloric, nitric, sulfuric, and perchloric acids.
Do not allow perchloric acid to come into contact with strong dehydrating agents concentrated sulfuric acid, anhydrous phosphorous pentoxide, etc. Perchloric acid must be stored where it will not freeze freezing point about 4f. See actual entry in rtecs for complete information. In solution of perchloric acid in glacial acetic acid by adding 8. Very hazardous in case of skin contact corrosive, irritant, of eye. Hazardous ingredients according to regulation ec no 1272. For samples with lower protein contents the final trichloroacetic acid concentration may be reduce to as low as 10 % wv by altering the ratio of trichloroacetic acid and sample appropriately. View or download the perchloric acid 7072% msds material safety data sheet or sds for 100519 from merck. The highly valued ammonium perchlorate can be produced electrochemically. Perchloric acid is a mineral acid with the formula hclo 4.
When working wit h concentrated acids, wear protective clothing. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. General description perchloric acid hclo 4, an oxygen acid of chlorine, is strongly acidic in nature. Seastar chemicals inc msds perchloric acid page 3 of 5 personal protective equipment eyes. L serum samples were cooled in an ice bath and mixed with perchloric acid 30.
The reaction of perchloric acid with bases, such as ammonium hydroxide, give salts. If perchloric acid will be heated, a special perchloric acid hood with water washdown system, and a safety shower will also be necessary. Perchloric acid is considered one of the strongest superacids. Even though use of these hoods by seb researchers and laboratory personnel should be uncomplicated. Perchloric acid extraction for nmr samples last modified 071510 5. It possesses some advantages over sulfuric acid, such as being monobasic, and having relatively few insoluble salts. This includes but is not limited to alcohols, amines, boranes, dicyanogen, hydrazines, hydrocarbons, hydrogen, nitroalkanes, powdered metals, silanes, or thiols bretherick 1979.
It is a clear, colorless, and odorless liquid typically found in aqueous form. Usually found as an aqueous solution, this colorless compound is a stronger acid than sulfuric acid and nitric acid. Material safety data sheet perchloric acid, 70% msds section 1. Samples shall consist of the vehicle portion of paints or small quantities of epoxy resin systems. Perchloric acid pca precipitation is one of the most extensively used deproteinization protocols since it not only removes most of the protein present in the sample but it also functions to stabilize many of the small molecule analytes. As the light shines through the filters, they switch to allow light we see change color as controlled by electrical components perchloric acid is vapour from perchloric acid is very dangerourss becasue it can condense into ventillation systems and form metallic perchlorates. Perchloric acid solution recommended use laboratory chemicals. Section 1 chemical product and company identification. First aid measures as a general rule, in case of doubt or if symptoms persist, always call a physician. Its oxidising potential is enhanced with increased temperature and pressure. Call 8005331710 or 5072665700 to order special collection tube. Perchloric acid mist and vapor can condense in ventilation systems to form metallic perchlorates, which can be explosive. However, perchloric acid can interfere in the analytical process, possibly by inhibiting the enzymes used.
Material safety data sheet perchloric acid, 60% msds utm. Perchloric acid is commonly used to denature and precipitate proteins in samples before various metabolites are measured in tissue, blood, and other body fluids. Quantitating metabolites in protein precipitated serum. Most perchloric acid is sold as solutions of 60% to 72% ww acid in water. Reaction with hydrochloric acid may form bischloromethyl ether, an osha regulated carcinogen. Safety data sheet according to 29cfr19101200 and ghs rev. Wear appropriate protective face shield and eyeglasses or chemical safety goggles as described by oshas eye and face protection regulations in 29 cfr 1910.
Perchloric acid and per chlorates are widely used in rocket propellant compositions which are highly corrosive to mild steel. Perchloric acid interference in enzymaticfluorimetric. It is a powerful oxidizer when hot, but aqueous solutions up to approximately 70% by weight at room temperature are generally safe, only showing strong acid features and. This chemical is considered hazardous by the 2012 osha hazard. On a smaller scale, robinson reported a detonation of 3g of a perchlorate salt of a rhodiumpolyamine complex undergoing an evaporation step in a rotary evaporator. A guideline for the use of perchloric acid and perchloric. How do i remove perchloric acid from my samples so that it. Uses advised against not for food, drug, pesticide or biocidal product use details of the supplier of the safety data sheet.
Perchloric acid revision date 18jan2018 general advice show this safety data sheet to the doctor in attendance. Identification product name perchloric acid cat no. Benzoic acid not listed as a carcinogen by acgih, iarc, ntp, or ca prop 65. Explosive or violent reactions with bromine pentaf luoride, chlorine trifluoride, chromic acid and anhydride, diallyl methyl carbinol and ozone, nitric acid, nitric acid and acetone, perchloric acid, permanganates, phosphorous trichloride, sodium peroxide, nxylene, azidotetrazole, phosphorous isocyanate, potassium hydroxide, hydrogen peroxide. Perchloric acid salts are generally very soluble in water except k, cs and rb. Even though use of these hoods by seb researchers and. This redox process often is referred to as nonoxidative hydrogen replacement by an active metal, but it is a redox.
Seastar chemicals inc msds perchloric acid page 2 of 5 ingestion. Chemtrec 8004249300 outside usa 7035273887 1216 6th ave n kent wa 98032 phone. It is a powerful oxidizer, but its aqueous solutions up to 70% are remarkably inert, only showing strong. Our msds database is an easy to use, do it yourself tool, and best of all. This msds has been prepared according to the hazard criteria of the controlled products. Under some circumstances it may act as an oxidizer andor present an explosion hazards. Inhalation move casualty to fresh air and keep at rest. Identification of the substancemixture and of the companyundertaking 1. These guidelines present information on how to handle and store perchloric acid safely. Holmium oxide in 10% perchloric acid solution1 x 10 ml perchloric acid solution 10% vv 1 x 10 ml validation date.
Eliminate or substitute for a less hazardous material when possible. A4691, a469250, a469500 casno 7601903 synonyms dioxonium perchlorate. Keep the quantities of perchloric acid handled at the bare minimum for safety. Information in this msds is from available published sources and is believed to be accurate. Page 1 of 2 perchloric acid university of michiganflint. Firstaid measures eyes immediately rinse with plenty of water for at least 15 minutes and seek medical attention immediately. Ph eur find msds or sds, a coa, data sheets and more information. A method for the preparation of perchloric acid caltechthesis. Perchloric acid acs reagent, 70% hclo4 sigmaaldrich. This method describes the collection and analysis of airborne sulfuric acid using ion chromatography. Curiously, perchlorate can be produced by lightning discharges in the presence of chloride. Pdf electrochemical reduction of perchlorate ions on.
Concentrated perchloric acid is used to disslove rocks and minerals for chemical analysis. The present study aims to understand the adsorption and inhibitive properties of 4n, n. Eye contact rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes. Add 1ml of 70% vv perchloric acid with 250 umol maleate and 5 umol methylphosphonate. It is a strong acid, very stable in solution, and has a high boiling point. Osha occupational chemical database occupational safety. It compiles information from several government agencies and organizations. Perchloric acid mist and vapor can condense in ventilation systems to form metallic perchlorates, which. Perchloric acid is a substance resembling sulfuric acid in many respects. Electrochemical reduction of perchlorate ions on ruthenium. It is by definition a superacid, with an acidity exceeding that of 100% sulfuric acid. Analytical methods the purpose of this chapter is to describe the analytical methods that are available for detecting, measuring, andor monitoring fluorides, hydrogen fluoride, and fluorine, its metabolites, and other.
Search results for perchloric acid at sigmaaldrich. It is a powerful oxidizer when hot, but aqueous solutions up to approximately 70% by weight at room temperature are generally safe, only showing strong acid features and no oxidizing properties. Never give anything by mouth to an unconscious person. Reacts violently with perchloric acid, perchloric acidaniline mixtures, and nitromethane. Hydrates of perchloric acid are obtained on its dissolution in water. September 2011 section 1 chemical product and company identification msds name. When we do this we use a mixture of nitric acid, hydroflouric acid, and perchloric acid for the initial digestion. Perchloric acid 70% msds material safety data sheet or sds, coa and coq.
All new locations used for heated perchloric acid procedures must be approved by environment, health and safety ehs at 810 7666763 prior to conducting any work. Verify that the types of compounds in the samples are soluble with the ashing procedure selected. Material safety data sheet perchloric acid west liberty. The use of hydrofluoric acid in the laboratory andy connelly. Perchloric acid can also become explosive when anhydrous which is a serious danger. Perchloric acid, 70% certified acs, fisher chemical.
Here are some examples of perchloric acid incompatible mixtures. When disposing of ppe exposed to perchloric acid, treat as hazardous waste. Seastar chemicals inc msds perchloric acid page 1 of 5 material safety data sheet perchloric acid print date. Examples of organic materials include paper or cotton. Perchloric acid, 70% acs columbus chemical industries.